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Thyroid Support l Previously known as TSP Thyroid Support Plus, supplies vitamins, minerals, amino acids, and botanical constituents to support the normal conversion of thyroid hormones, T-4 to T-3. In the bloodstream, T3 and T4 are carried by thyroxine-binding globulin, thyroxine-binding preablumin and serum albumin. T4 is converted to T3 by the liver, lungs, kidneys, and heart by a selenium-dependent enzyme called Iodothyronine-5'monodeiodinase. T3 is then taken up by appropriate target cells, where it is transported to the nucleus to activate transcription.